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Chronic Lymphocytic Leukemia (CLL)

In this article, we have covered the following:

  • Best Hospitals in India for treatment of CLL
  • Best Hemato Oncologists for CLL treatment
  • Cost of CLL treatment in India
  • Understanding CLL, Causative factors

Best Hospitals in India for treatment of CLL

HospitalCityHospital Page link
Fortis Memorial Research Institute, Gurgaon Gurgaon, IndiaVisit hospital page, contact
Medanta – The Medicity, Gurgaon Gurgaon, IndiaVisit hospital page, contact
BLK Super Specialty Hospital, New Delhi New Delhi, IndiaVisit hospital page, contact
Kokilaben Hospital, Mumbai Mumbai, IndiaVisit hospital page, contact
Apollo Hospital, Chennai Chennai, IndiaVisit hospital page, contact
Indraprastha Apollo Hospital, New Delhi New Delhi, IndiaVisit hospital page, contact
Artemis Hospital, GurgaonGurgaon, IndiaVisit hospital page, contact
Max Super Specialty Hospital, New Delhi New Delhi, IndiaVisit hospital page, contact
Global Hospital ChennaiChennai, IndiaVisit hospital page, contact
Mazumdar Shaw Cancer Centre (MSCC), Bangalore Bangalore, IndiaVisit hospital page, contact
Fortis Flt. Lt. Rajan Dhall Hospital, New Delhi New Delhi, IndiaVisit hospital page, contact
Fortis Hiranandani Hospital, Vashi, Mumbai Mumbai, IndiaVisit hospital page, contact
Jaypee Hospital, Noida Noida, IndiaVisit hospital page, contact
Fortis Hospital, Bangalore Bangalore, IndiaVisit hospital page, contact
MaxCure Hospital, Hyderabad Hyderabad, IndiaVisit hospital page, contact
Fortis Hospital, Mulund, MumbaiMumbai, IndiaVisit hospital page, contact
Fortis Malar Hospital, Chennai Mumbai, IndiaVisit hospital page, contact
Global Hospital, Mumbai Mumbai, IndiaVisit hospital page, contact
Narayana Institute of Cardiac Sciences, Bangalore Bangalore, IndiaVisit hospital page, contact
S. L. Raheja Hospital, Mumbai Mumbai, IndiaVisit hospital page, contact
SIMS Hospital, Chennai Chennai, IndiaVisit hospital page, contact
Sri Ramakrishna Hospital, Coimbatore Coimbatore, IndiaVisit hospital page, contact
Wockhardt Hospitals, Mumbai Mumbai, IndiaVisit hospital page, contact

Best Hemato Oncologists for CLL treatment

DoctorSpecialtyCityCheck profile, contact
Dr. Rahul BhargavaHaemato Oncologist & Bone Marrow Transplant SpecialistGurgaonCheck profile, contact
Dr. Ashok Kumar VaidHaemato Oncologist & Bone Marrow Transplant SpecialistGurgaonCheck profile, contact
Dr. Vikas DuaPaediatric Haemato Oncologist & Bone Marrow Transplant SpecialistGurgaonCheck profile, contact
Dr. Dharma ChoudharyHaemato Oncologist & Bone Marrow Transplant SpecialistDelhiCheck profile, contact
Dr. Satya Prakash YadavPaediatric Haemato Oncologist & Bone Marrow Transplant SpecialistGurgaonCheck profile, contact
Dr. Santanu SenHaemato OncologistMumbaiCheck profile, contact
Dr. Hari GoyalHaemato OncologistGurgaonCheck profile, contact
Dr. Prantar ChakrabartiHaemato OncologistKolkataCheck profile, contact

Cost of CLL treatment

Unfortunately, we are not able to share the cost of this treatment as we are still awaiting response from few hospitals before publishing the cost. However, you may share your medical reports and we will share the cost of treatment from the hospital recommended for you.

How to proceed for treatment

Medgurus Services

Understanding CLL

Chronic Lymphocytic Leukemia (CLL) is a blood cancer type in which the bone marrow makes too many lymphocytes (a kind of white blood cell). It mostly affects men above 55 years of age. Though the disease is rarely curable, but patients can live for many years through effective treatment measures.

Cause of CLL

As observed in most cancers, there is no certain cause of chronic lymphocytic leukemia. It is suspected to be an inherited disorder as rare instances of family history of CLL have been reported.

CLL is found to be extremely rare in Asian natives and higher among whites than blacks.

Signs and symptoms of CLL

Usually patients with CLL have no symptoms. About 25-50% of patients are asymptomatic at time of diagnosis. The disease is mostly discovered incidentally after a blood cell count is done for some other reason.

It is advisable not to ignore the below symptoms, as these may be signs of CLL:

  • Swollen lymph nodes in your neck, armpits, stomach, or groin
  • Shortness of breath, extreme fatigue
  • Loss of appetite and weight
  • Pain or fullness in stomach
  • Excessive sweating during nights longer than one month
  • Fever longer than two weeks and infections
  • Anemia or thrombocytopenia
  • Progressive or symptomatic enlargement of the spleen
  • Progressive lymphocytosis (increase in lymphocytes count in blood)

Investigations for CLL

  • CBC with peripheral smear
  • Bone marrow aspiration and biopsy with flow cytometry (not required in all cases of CLL)
  • Ultrasound whole abdomen
  • Chromosomal test – Additional molecular testing that may help predict prognosis or clinical course
  • Lymph node biopsy – If lymph nodes enlarge rapidly, the biopsy is done to assess the possibility of change into a high-grade lymphoma.

Staging of CLL

As per the Rai-Sawitsky staging system CLL patients are categorized as below:

  • Low risk (stage 0) – Lymphocytosis in the blood and marrow only
  • Intermediate risk (stages I and II) – Lymphocytosis with enlarged nodes in any site or splenomegaly (spleen enlargement) or hepatomegaly (enlarged liver)
  • High risk (stages III and IV) – Lymphocytosis with disease-related anemia (hemoglobin < 11 g/dL) or thrombocytopenia (platelets < 100 x 10 9/L)

Aggressive forms of CLL

Prolymphocytic Leukemia (PLL) and Hairy Cell Leukemia (HCL) are two types of aggressive chronic B-cell leukemia. B-cells are a type of lymphocyte that makes antibodies for the immune system.

Prolymphocytic Leukemia (PLL)

Prolymphocytic Leukemia (PLL) involves presence of large number of immature lymphocytes in the blood. It may occur on its own, along with CLL, or CLL may transform into PLL.  PLL is more aggressive than CLL.

Hairy Cell Leukemia (HCL)

Hairy Cell Leukemia (HCL) is a slow-growing form of CLL. It is known as hairy cell because the abnormal lymphocytes have hair-like projections, which multiply in the bone marrow, blood, and spleen. These abnormal lymphocytes fail to fight diseases and infection. Eventually, these overgrow in number than the healthy cells.

Management of CLL

Early stages of CLL are not treated as the treatment (chemotherapy) has failed to show benefit. The treatment starts only when your doctor notices rapid progression of disease such as increase in lymphocytes count, decrease in RBCs count, or increase in lymph node swelling. The five-year survival rate of CLL is 75%.

The CLL treatment involves:

Chemotherapy: Combination regimens of chemotherapy have shown improved response rates

Bone Marrow Transplant: Allogenic bone marrow (stem cell) transplant, in which matching donor is required, is the only known curative therapy for CLL.

 

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