Chronic Myelogenous Leukemia (CML)
In this article, we have covered the following aspects of Chronic Myelogenous leukemia (CML):
- Best Hospitals for treatment of CML
- Top Hemato Oncologists for treatment of CML
- Cost of CML treatment in India
- Understanding Chronic Myelogenous Leukemia
Best Doctors and Hospitals for treatment of CML
Following is a list of the most reputed specialists in India for the treatment of Chronic Myelogenous Leukemia.
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Cost of treatment for CML in India
Unfortunately, we are not able to share the cost of this treatment as we are still awaiting response from few hospitals before publishing the cost. However, you may share your medical reports and we will share the cost of treatment from the hospital recommended for you.
Understanding Chronic Myelogenous leukemia
In Chronic Myelogenous Leukemia (CML), the bone marrow makes immature granulocytes (a type of white blood cells), which interfere with the normal production of blood cells. The immature WBCs from the bone marrow enter into the bloodstream throughout the body, which leads to anemia and bleeding. Mostly CML occurs in male adults compared to females and rarely develops in children. Also known as Chronic Myeloid Leukemia, it accounts for 20% of all leukemia patients.
CML is caused by a single, specific genetic mutation and progresses through three phases – chronic, accelerated, and blast. In most cases, the disease is diagnosed in the chronic phase, which then progresses to the accelerated and blast phases after three to five years.
Signs and symptoms of CML
- Fatigue, weight loss, loss of energy, decreased exercise tolerance
- Fever, excessive sweating
- Anemia, unexplained bleeding
- Frequent or repeated infections and slow healing
- Increase in WBC count or enlargement of spleen on routine assessment
- Fullness and decreased food intake
- Left upper abdominal pain from spleen infarction
- Hepatomegaly (enlarged liver)
- Symptoms of progressive phase CML (accelerated and blast phase):
- Bleeding, petechiae, and ecchymoses during the acute phase
- Bone pain and fever in the blast phase
- Increasing anemia, thrombocytopenia, basophilia, and a rapidly enlarging spleen
Investigations required in CML
- CBC with differential
- Peripheral blood smear
- Bone marrow analysis
The definitive diagnosis of CML is based on the following:
- Histopathologic findings in the peripheral blood
- Philadelphia (Ph) chromosome in bone marrow cells
Treatment of CML
The treatment of CML varies with the phase of disease, age, and general health of the patient. The goal of the treatment during the chronic phase is to control CML and keep the blood counts within a normal range. The treatment in the accelerated and blast phase is more intensive.
The treatment of CML involves:
- Bone Marrow Transplant
Bone marrow transplant is the only hope chance for a definitive cure for Chronic Myeloid leukemia. Ideally, allogenic BMT is performed in the chronic phase of the disease with a matched or single-antigen-mismatched related donor. Overall survival of allogenic BMT via matched unrelated donors is 31% to 43% for patients younger than 30 years, and from 14% to 27% for older patients.
Note (for foreign patients):
Besides South Asian countries (Afghanistan, Bangladesh, Bhutan, Maldives, Nepal, Pakistan, Sri Lanka), every year, India gets thousands of medical tourists from African countries- Nigeria, Kenya, Ethiopia, Sudan, Uganda, Ghana, Somalia,Gambia etc and Middle Eastern countries like Iraq, Iran, Saudi Arabia, Oman, UAE, Yemen etc. Hence, if you are a citizen of any of these countries, there is good likelihood that you will be meeting some fellow citizens or same language speakers in the major hospitals in India. Almost all the top hospitals have translators for people of these region. Our patient support team is also well placed to assist you.