Non-Hodgkin Lymphomas (NHLs)

In this article, we have covered the following aspects of NHLs:

  • Best Hospitals for treatment of Non Hodgkin Lymphomas
  • Top Oncologists expertised in treating NHLs
  • Cost of Treatment of NHLs
  • Understanding Non-Hodgkin Lymphomas

Best Doctors and Hospitals for treatment of Non Hodgkin Lymphomas

Following is a list of the most reputed specialists in India for the treatment of Non-Hodgkin Lymphomas.
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Doctor ImageDr. NameSpecialtyHospital AssociatedContact DoctorCity
Dr. Rahul BhargavaDr. Rahul BhargavaHaemato OncologistFortis Memorial Research InstituteGurgaon
Dr. Vikas DuaDr. Vikas DuaHaemato OncologistFortis Memorial Research InstituteGurgaon
Dr. Prantar ChakrabartiDr. Prantar ChakrabartiHaemato OncologistFortis Hospital AnandapurKolkata
Dr. satya prakash yadavDr. Satya Prakash YadavHaemato OncologistMedanta - The MedicityGurgaon
Dr Hari GoyalDr. Hari GoyalHaemato OncologistArtemis HospitalGurgaon
Dr Santanu SenDr. Santanu Sen Haemato OncologistKokilaben Dhirubai Ambani HospitalMumbai
Dr. Shishir SethDr. Shishir SethHaemato OncologistIndraprastha Apollo HospitalNew Delhi
Dr Dharma ChoudharyDr. Dharma ChoudharyHaemato OncologistBLK Super Specialty HospitalDelhi
Dr. Sharat DamodarDr. Sharat DamodarBone Marrow TransplantNarayana Multispeciality HospitalBangalore

Doctor ImageDr. NameSpecialtyHospital AssociatedContact DoctorCity
Dr. Vinod RainaDr. Vinod Raina Medical OncologistFortis Memorial Research InstituteGurgaon
Dr Niti Raizada NarangDr. Niti Raizada NarangMedical OncologistFortis HospitalBangalore
Dr. Ashok Kumar VaidDr. Ashok Kumar VaidMedical OncologistMedanta - The MedicityGurgaon
Dr Rakesh ChopraDr. Rakesh ChopraMedical OncologistArtemis HospitalGurgaon
Dr RajasundaramDr RajasundaramMedical OncologistGlobal HospitalsChennai
Dr Bellarmine LawrenceDr Bellarmine Vincent LawrenceMedical OncologistGlobal HospitalsChennai
Dr Amit AgarwalDr. Amit AgarwalMedical OncologistBLK Super Specialty HospitalDelhi
Dr Boman DhabharDr. Boman Nariman DhabharMedical OncologistWockhardt HospitalsMumbai

Cost of Treatment of NHLs

Unfortunately, we are not able to share the cost of this treatment as we are still awaiting response from few hospitals before publishing the cost. However, you may share your medical reports and we will share the cost of treatment from the hospital recommended for you.

Understanding Non-Hodgkin lymphomas (NHLs)

  • Non-Hodgkin lymphomas are tumors originating from lymphoid tissues, mainly of lymph nodes. chromosomal translocations, infections, environmental factors, immunodeficiency states, and chronic inflammation may result in these tumors
  • NHL is classified into those of B-cell origin and those of T-cell and natural killer (NK)–cell origin
  • Almost 85% of NHLs are of B-cell origin; only 15% are derived from T/NK cells
  • NHL is the most prevalent hematopoietic neoplasm
  • Ranking seventh in frequency among all cancers. NHL is more than 5 times as common as Hodgkin disease
  • Incidence varies with race; white people are at high risk than black and Asian American people
  • In general, the incidence of NHL is slightly higher in men than in women (1.4:1)
  • The median age at presentation for most subtypes is older than 50 years

Stages of NHLs:

NHL is divided into 4 stage according to location and number of lymph node involvement:

Stage 1:  One group of lymph nodes is affected.
Stage 2:  The lymphoma is in two or more groups of lymph nodes on the same side of the diaphragm (above or below). The diaphragm is a sheet of muscle under the lungs.
Stage 3:  The lymphoma is on both sides of the diaphragm (both above and below it).
Stage 4:  The lymphoma has spread beyond the lymph nodes to other organs, such as the bone marrow, liver or lungs.

Signs & Symptoms

Signs and symptoms of low-grade lymphomas include the following:

  • Peripheral adenopathy: Painless and slowly progressive; can spontaneously regress
  • Bone marrow: Frequent involvement; may be associated with cytopenias ; fatigue/weakness more common in advanced-stage disease
  • Intermediate- and high-grade lymphomas have a more varied clinical presentation, including the following:
    • Adenopathy: Most patients
    • Extranodal involvement: most common sites are GI/GU tracts , skin, bone marrow, sinuses, thyroid, CNS
    • Temperature >38 C, night sweats, weight loss >10% from baseline within 6 months.

Diagnosis of Non-Hodgkin Lymphomas

Examination in patients with low-grade lymphomas may demonstrate peripheral adenopathy, splenomegaly, and hepatomegaly.

Intermediate- and high-grade lymphomas may result in the following examination findings:

  • Rapidly growing and bulky lymph nodes
  • Splenomegaly
  • Hepatomegaly
  • Large abdominal mass: Primarily in Burkitt lymphomaTesticular mass
  • Skin lesions


Laboratory studies in a patient with suspected NHL should include the following:

  • Complete blood count
  • Biochemistry studies: May show elevated LDH and calcium levels, abnormal liver function tests
  • Elevated Serum beta2-microglobulin level
  • HIV serology
  • Human T-cell lymphotropic virus-1 serology: For patients with adult T-cell leukemia/lymphoma
  • Hepatitis B testing

Other tests that may be helpful in evaluating suspected NHL include the following:

  • Immunophenotypic analysis of lymph node, bone marrow, peripheral blood
  • Cytogenetic studies

Imaging Tests

The following imaging studies should be obtained in a patient suspected of having NHL:

  • Chest radiography
  • Upper GI endoscopy
  • CT scan neck, chest, abdomen, and pelvis
  • PET scan
  • Bone scan
  • Testicular ultrasonography: For opposite testis in male patients where primary lesion is testes
  • Multiple gated acquisition (MUGA) scanning: For patients being considered for treatment with chemotherapy
  • MRI of brain/spinal cord: For suspected primary CNS lymphoma


The diagnosis of NHL relies on pathologic confirmation following appropriate tissue biopsy:

  1. Bone marrow aspiration and biopsy: For staging rather than diagnostic purposes
  2. Excisional lymph node biopsy (extranodal biopsy)

Treatment of NHLs

The treatment of NHL varies greatly, depending on various factors. Common therapies include the following:

  • Chemotherapy: Most common; usually combination regimens
  • Radiation therapy
  • Monoclonal antibody therapy
  • Bone marrow transplantation: Possible role in relapsed high-risk disease
  • Radioimmunotherapy
  • Transfusions of blood products
  • Antibiotics
  • Pharmacotherapy
  • Surgery-Surgical intervention in NHL is limited but can be useful in selected situations

The prognosis for patients with NHL depends on the following factors:

  • Tumor histology
  • Tumor stage
  • Patient age
  • Tumor bulk
  • Performance status
  • Serum lactate dehydrogenase (LDH) level
  • Beta2-microglobulin level
  • Presence or absence of extranodal disease

Note (for foreign patients):

Besides South Asian countries (Afghanistan, Bangladesh, Bhutan, Maldives, Nepal, Pakistan, Sri Lanka), every year, India gets thousands of medical tourists from African countries- Nigeria, Kenya, Ethiopia, Sudan, Uganda, Ghana, Somalia,Gambia etc and Middle Eastern countries like Iraq, Iran, Saudi Arabia, Oman, UAE, Yemen etc. Hence, if you are a citizen of any of these countries, there is good likelihood that you will be meeting some fellow citizens or same language speakers in the major hospitals in India. Almost all the top hospitals have translators for people of these region. Our patient support team is also well placed to assist you.

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